4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid
4-[(E)-{4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid
CAS: 307510-92-5
Molecular Formula: C18H10F3NO3S2
4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid - Names and Identifiers
4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid - Physico-chemical Properties
| Molecular Formula | C18H10F3NO3S2 |
| Molar Mass | 409.4 |
| Density | 1.61±0.1 g/cm3(Predicted) |
| Melting Point | 181-183 °C |
| Boling Point | 555.7±60.0 °C(Predicted) |
| Flash Point | 289.9°C |
| Solubility | DMSO: ≥10mg/mL |
| Vapor Presure | 3.48E-13mmHg at 25°C |
| Appearance | Yellow solid |
| Color | yellow |
| pKa | 3.88±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.698 |
| In vitro study | CFTRinh-172 inhibited CFTR-mediated iodide transport in a time-and dose-dependent manner, and effectively inhibited CFTR activation mediated by multiple agonists or activators. As a selective CFTR channel inhibitor, CFTRinh-172 was also able to completely block chloride flow in the acinar and duct cells of the lacrimal gland of rabbits. CFTRinh-172 induced production of ROS, mitochondrial damage, and activation of the NF-κB signaling pathway by a CFTR-independent mechanism. |
| In vivo study | CFTRinh-172 (20 µg/6 h) completely blocked V. Cholerae-induced intestinal fluid secretion without affecting V. Cholerae in vivo proliferation. |
4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.443 ml | 12.213 ml | 24.426 ml |
| 5 mM | 0.489 ml | 2.443 ml | 4.885 ml |
| 10 mM | 0.244 ml | 1.221 ml | 2.443 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.489 ml |
Last Update：2024-01-02 23:10:35
4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid - Reference Information
| Biological activity | CFTRinh-172 is a selective CFTR inhibitor with potential difference dependence, Ki is 300 nM, for MDR1,ATP-sensitive potassium ion channels or A series of transporters have no effect. CFTRinh-172 (CFTR inhibitor 172) is a selective CFTR inhibitor with potential difference dependence, Ki is 300 nM, and has no effect on MDR1,ATP-sensitive potassium ion channels or a series of transporters. |
| Target | Value |
| CFTR (in human airway cells) | 300 nM(Ki) |
Last Update：2024-04-09 21:04:16
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Product Name: CFTRinh-172 Visit Supplier Webpage Request for quotationCAS: 307510-92-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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